The database of gene expression in HIV and SIV host immune response

Welcome to HIHISIV

In the battle of the host against lentiviral pathogenesis, the immune response is crucial. However, several questions remain unanswered about the interaction with different viruses and their influence on disease progression. The simian immunodeficiency virus (SIV) infecting nonhuman primates (NHP) is widely used as a model for the study of the human immunodeficiency virus (HIV). They share physiological and anatomical similarities that are largely explored to understand pathogenic and non-pathogenic disease progression.

The HIHISIV database was developed to integrate and evaluate the large number of transcriptional data associated with the presence/absence of the pathogen and the host response. In this way, HIHISIV database support researchers to enhance the knowledge of HIV and SIV with a significant impact on human and animal health.

The information was manually collected from published literature and records in the repositories transcriptome data. This database was developed and maintained by Dexl Lab from National Laboratory for Scientific Computing - LNCC.

Publication

Costa, R.L., Gadelha, L., D’arc, M. et al. HIHISIV: a database of gene expression in HIV and SIV host immune response. BMC Bioinformatics 25, 125 (2024). https://doi.org/10.1186/s12859-024-05740-7.

CONTACT

If you have any question, send an email to: hihisiv@protonmail.com.

CHANGELOG

July, 2023
- Second version 2.0
- versions of packages and libraries
  - affy (Methods for Affymetrix Oligonucleotide Arrays): 1.78.2
  - biomart (Interface to BioMart databases (i.e. Ensembl)): 2.56
  - GEOquery (Get data from NCBI Gene Expression Omnibus, GEO): 2.68.0
  - rols (An R interface to the Ontology Lookup Service): 2.28.0
  - GOstats (Tools for manipulating GO and microarrays): 2.66.0
  - limma (Linear Models for Microarray Data): 3.56.2
  - GenomicFeatures (Conveniently import and query gene models): 1.52.1
- add enrichment analysis (biological process, GO)
- new table: Ontology_terms from metadata
- database schema renewed
July, 2022
- Second update 1.10;
- More datasets included;
- Added transcripts query module.
January, 2022
- First version 1.0

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.